FLUIDS iQ® News
Intestinal iQ™ - The New Way to Assess Intestinal Status
FLUIDS iQ® recently launched our updated series of intestinal tests, featuring our triad of Zonulin, Diamine Oxidase\Histamine and Total IgG food sensitivity tests. We call it Intestinal iQ™ and it comes with an enhanced graphic layout of the results together with a detailed interpretation.
Why Intestinal iQ™?
FLUIDS iQ® is continually striving to provide wellness professionals with innovative and clinically useful tests. Our Zonulin test has been extremely well received, often being called a ‘game changer’ by those who use it. In combination with Total IgG for 24 or 88 foods it has proven to be an extremely useful screening tool of intestinal status. Ongoing research and clinical studies, together with numerous requests from the health care community, has led to our decision to add a third test to our series – the Diamine Oxidase (DAO) / Histamine test.
Histamine is well known as one of the principle pro-inflammatory proteins, responsible for a myriad of allergic responses in the body, including increases in gastric acid secretion, intestinal inflammation and permeability. DAO is the main enzyme that breaks down histamine in the intestine and helps to maintain gastrointestinal balance.
Why Use Intestinal iQ™ tests?
Each of the tests in the Intestinal iQ™ series is useful in and of themselves. When combined, however, they paint a vivid portrait of an individual’s gut status that is unattainable when testing individual markers alone.
Zonulin, our test for “leaky gut”, is the foundational test in the Intestinal iQ™ series. Foods, nutrients, medications, alcohol, pesticides, toxins, viruses, bacteria, and fungus all come into intimate contact with the body through the gut. When the gut barrier becomes damaged by food allergens, chemicals, antibiotics, or infection, this important barrier function can be compromised, leading to increased intestinal permeability, or “leaky gut”.
The Importance of testing the complete triad, by adding our DAO\H and Total IgG food sensitivity tests.
Including an analysis of DAO/H enhances the portrait begun with the Zonulin screening test by assessing levels of allergic inflammation and the body’s ability to decrease inflammation in the gut. DAO and Histamine can tell if there are problems breaking down Histamine, or if there is inflammation causing allergic-type symptoms. If there are GI symptoms such as reflux, irritable bowel disease, chronic diarrhea, or food sensitivities, then this test profile helps in finding the underlying causes of these symptoms.
When Zonulin is used together with our DAO/H and Total IgG-24 or 88 foods panels, the combined profile gives a very clear and powerful portrait of the following:
1) The enzymatic and dysbiotic effects on GI function (Total IgG 24 or 88)
2) Inflammatory and permeability changes, both local and regional (DAO/H)
3) Intestinal permeability changes (Zonulin)
These three tests, when done in combination, provide unparalleled clarity in determining the state of intestinal health.
To make the reading of the test reports as clear as possible, we have also designed a short presentation on the that provides a guide, in words and colour graphics, to the interpretation of the results. Please click on the link below to see this presentation.
The Art of Using Functional Testing - A Free Webinar Feb 20 @ 8 PM EST
FLUIDS iQ is proud to be partnering with Clinician Business Labs on what promises to be an exciting and inspiring webinar to kick start the year.
Join Naturopathic Doctor and Business Coach, Dr. Meghan Walker as she explores The Art of Functional Testing – Clinical and Business Cases for greater impact.
As Dr. Meghan explains:
Functional testing is a clinical tool that can differentiate your practice. But, we’re guessing you are not always sure about how to position the cost or value.
Individuals seek your care, when their desire for insight exceeds their own ability to search the Google, read books or follow the advice of friends. Your ability to provide targeted and informed insight into their health, is precisely why people are investing in your knowledge.
Despite knowing all of this, one of the greatest hurdles, still faced by many clinicians, is how to position the testing so that it doesn’t feel salesy, pushy or frankly, disingenuous. Overcoming these feelings requires a shift in mindset and a distinct strategy about how you position the benefits and cost of the test.
The LIVE webinar will be held on February 20th, 8pm EST
In this FREE Webinar Training you will learn:
• Why testing is so important, how it validates what we do and how it provides concrete evidence and a baseline marker.
• The importance of a process that lends itself to lab testing.
• Where to position testing during an appointment to maximize compliance.
• How to talk about price, costs and payments without feeling like you are taking advantage of your patients.
Let's Do This!
Introducing Intestinal iQ™
FLUIDS iQ® is proud to announce the launch of Intestinal iQ™, our newest approach to the “gut”, featuring the FLUIDS iQ® “triad” of Zonulin, Diamine Oxidase\Histamine and Food Sensitivity testing.
About Intestinal iQ™
The FLUIDS iQ® series of easy to use Intestinal iQ™ wellness tests are focused on three key areas, which we call the “triad”:
• Intestinal permeability (“Leaky Gut”);
• Enzymatic and bacterial imbalances
“Leaky Gut”: FLUIDS iQ® ’s Zonulin test
FLUIDS iQ® ’s industry-leading dried blood spot Zonulin test for “Leaky Gut” is the foundation of all Intestinal iQ™ testing. “Leaky Gut” is a condition that occurs when the gut lining becomes abnormally permeable, allowing bacteria, large food derived molecules and toxins to pass through. A major controller of this gateway is Zonulin, a protein found in intestinal cells. Zonulin testing is a very useful first line screening test in beginning to paint a portrait of an individual’s gut status.
Intestinal Inflammation: FLUIDS iQ® ’s Diamine Oxidase\Histamine Test
Histamine (H), an organic compound, is involved in many types of allergic and inflammatory processes and helps regulate gut function. Diamine Oxidase (DAO) is the body’s primary enzyme for breaking down histamine. Histamine excess may result from insufficient DAO, or consumption of histamine rich foods.This second test in our Intestinal iQ™ triad, theDAO\H test, builds on the first and provides important information that standard food sensitivity tests may not reveal.
Enzymatic and Bacterial Imabalance: FLUIDS iQ® ’s Total IgG Food Sensitivity test
Food sensitivity is a result of immune reactions, with symptoms generally limited to the gut. This distinguishes it from food “allergy”, which may cause severe, life threatening, allergic reactions (anaphylaxis). FLUIDS iQ® ’s Total IgG 24 or 88 Foods Panels help determine the possible source of enzyme imbalances, such as stomach, pancreas and/or biliary system as well as bacterial imbalance (dysbiosis). When used together with the tests for “Leaky Gut” (Zonulin) and inflammation (DAO/H), they give an even clearer picture of gut function, a vital aid in determining treatment.
Intestinal iQ™ tests are all easy to use, dried blood spot tests. They are offered alone or in combination. Please call or email us to order your testing kits today!
The FLUIDS iQ® Diamine Oxidase (DAO)/Histamine Test
FLUIDS iQ® is proud to be launching a new addition to our line of dried blood spot wellness tests: The DAO/Histamine test for monitoring intestinal inflammation. Our test reports will show both the levels of DAO and Histamine as well as the their ratio, which is a quick way of highlighting potential imbalances.
Histamine is a bioactive amine that is produced in the body in response to an injury or foreign substance, which includes many foods. Its physiological effects include increasing blood supply, regulation of gastric acid and blood vessel permeability, as well as a normal response to inflammation. The highest concentrations are found in the gastrointestinal tract, skin and lungs, with smaller amounts in the heart and brain.
In healthy individuals, dietary histamine can be rapidly detoxified by DAO, the main enzyme for the metabolism of ingested histamine. The level of histamine in the blood, after eating histamine-rich foods, depends on its passage through intestinal cells, or enterocytes. DAO, located in the enterocyte cytoplasm, is important in inactivating histamine before it enters the blood system.
An impaired histamine degradation due to reduced DAO activity, and the resulting histamine excess, may create symptoms that mimic an allergic reaction. This "Histamine Intolerance (HIT)" results from a disequilibrium of accumulated histamine and the capacity for histamine degradation.
The ingestion of histamine-rich food, alcohol or drugs, that release histamine or block DAO, may provoke headaches, diarrhea, rhino and conjunctival symptoms, hypotension, asthma, arrhythmia, urticaria, pruritus, flushing, and other conditions that comprise the entity known as histamine intolerance. Symptoms can be reduced by a histamine-free diet or be eliminated by antihistamines.
Studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.1 Certain medications may affect histamine balance in the body by promoting histamine release or inhibiting DAO.2
Total histamine load must be considered when evaluating histamine intolerance, and a balance, or ratio, between DAO and histamine appears to be crucial to maintaining gastrointestinal, skin and rhino-conjunctival health.
1. Komericki P, Klein G, Reider N, et al. Histamine intolerance: lack of reproducibility of single symptoms by oral provocation with histamine: a randomised, double-blind, placebo-controlled cross-over study. Wien Klin Wochenschr. 2011;123:15-20.
2. Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr 2007;85:1185-1196.
FLUIDS iQ®'s New Look Zonulin Report
FLUIDS iQ® is excited to announce an update to our Zonulin reports, including an enhanced graphic layout of the results.
Why an updated report?
Analysis of accumulated data from a high volume of Zonulin samples prompted us to refine the present measurable reference range of 5-25 ng/ml to the new, revised range of 1-20 ng/ml. In addition, the depiction and explanation of the Zonulin result now has an enhanced graphic layout , as well as a more detailed result interpretation.
This update will provide the reader with a Zonulin value that is more closely related to the clinical picture and less prone to misinterpretation.
What are the Changes and their Meaning?
The “measurable (reference) range” shown in the reports up to now, has been interpreted by many as meaning the “normal range”, implying that people who have Zonulin levels within this range should have normal intestinal function and should not be showing signs and symptoms of intestinal permeability problems.
That is not the case. The “reference range” in this report is defined as the range of values derived from a normal distribution of results that encompass 95% of randomly selected individuals in a population.
In other words, this range of values includes individuals with normal intestinal function, through to those who have some form of overt or diagnosed inflammatory and/or autoimmune condition. To be sure that this definition is clearly understood, it has been written just below the Zonulin colour bar, next to the asterisk (*)
To further emphasize how the Zonulin values relate to permeability change, the horizontal bar has also been divided into three sections, each with its separate colour and word description:
• Green for Optimal (1-6 ng/ml)
• Yellow for Borderline (6-10 ng/ml)
• Red for Elevated (10 to 20 ng/ml). Some individuals who are in an acute inflammatory or auto-immune state may show values well above the 20 ng/ml, in some cases reaching beyond 40-50 ng/ml.
We hope that the changes in the report, outlined above, will lead to much easier interpretation.
Zonulin and Intestinal Permeability - A Lecture by Dr. Aron Gonshor, President and CEO of FLUIDS iQ®
As part of our commitment to offering the highest standards of laboratory service products and to make available tests that are at the state of the art in biomarker science, FLUIDS iQ® is proud to announce the launch of North America's first commercially available test for Zonulin, the prehaptoglobin 2 protein that is recognized as a key biomarker in determining changes in intestinal permeability.
This test is quickly becoming an important part of an assessment of what is commonly referred to as “Leaky Gut” and will allow clinicians to use objective evidence in determining the clinical state of their patients.
The test for Zonulin represents only one of a number of such biomarkers tests that FLUIDS iQ® will be launching in the near future, in order to give the clinician ever greater ammunition in the targeting of individualized diagnosis and treatment.
FLUIDS iQ® ’s Zonulin test is offered as a single test as well as part of the Zonulin-24 or Zonulin-88 tests, which combine analyses of Zonulin together with a total IgG antibody response to 24 or 88 common food types.
To learn more about FLUIDS iQ® ’s Zonulin tests and for the literature on Zonulin, click here.
During the month of May, Naturopath Week(s) will be taking place across Canada - these are opportunities for the general public to learn more about wellness and good health through conferences, seminars, culinary workshops and free consultations offered by the naturopath community. You can learn more about these exciting, annual week(s) of wellness and what's taking place in your neighborhood by visiting the websites of the Canadian Association of Naturopathic Doctors at www.cand.ca and l'Association des Naturopathes Agréés du Quebec at www.anaq.ca
Teeth brushing and flossing are the key to good oral hygiene. This has long been known. But there are key bacteria found in saliva that are not only implicated in gum disease but, moreover, when they enter the blood stream have been indicated in more serious systemic diseases. In a paper presented in the journal Immunity, co-authors Dr. Ofer Mandelboim and Dr. Gilad Bachrach found that one of these key bacteria, F. nucleatum, could “collude with colon cancer cells to inhibit an immune cell receptor called TIGIT – a natural body defense to the spread of cancer."
Read the article in the Times of Israel.
FLUIDS iQ® is excited to share the news that the 1st Annual North American Saliva Symposium (NASS), a historic event that will bring together many of the worlds leaders involved in the field of saliva science and diagnostics, will take place in Boston this October 24th-26th.
According to organizers, the NASS "is an opportunity for salivary researchers and industry players to be involved in sessions covering Dentistry, Medicine, Pediatrics, Industry, and other disciplines where they can meet, share ideas, and conceive the next generation of salivary technologies that will benefit human health in the future."
To learn more about this historic occasion and how you can participate, please click the link to the NASS website below.
See you in Boston!
This year marks a watershed in FLUIDS iQ® ’s development as a company. In the fall we will be launching an all new division, devoted to offering tests for humans aimed at promoting wellness and overall health. Today we are living longer lives than ever before in our history. And with the arrival of the information age our curiosity and understanding of what goes into sustaining our wellness and overall health is increasing by leaps and bounds. Whether it’s getting to know more about our hormones, or the how’s and why’s affecting our intolerances and allergies to the foods we eat, we want to know more about our bodies and how to live better lives. To this end, we are looking forward to working with you to offer the kind of tests that go hand in hand with this incredible evolution in life sciences.
Our animal test division is on the cusp of something incredible. Our Pet Perio™ test, a DNA saliva test for periodontal disease in animals, dogs and cats in particular, will be brought to market in the coming months. This test, the first of its kind in the world, goes beyond traditional, subjective methods of diagnosing disease through physical signs and symptoms. Instead, by analysing saliva, the Pet Perio™ test identifies the presence and concentration of the key bacteria that cause periodontal disease and offers a risk assessment based on bacterial concentration, clinical evaluation and breed as well as recommendation for retesting and treatment options. This test will revolutionize dental care for our cherished companions who in many ways have become vital members of our families. In doing so we believe the Pet Perio™ test will aid in prolonging their lives and allowing us to enjoy their company as we continue to live longer as well.
It’s an exciting time here at FLUIDS iQ® and we look forward to working with you.
FLUIDS iQ® laboratory testing services now available to U.S. health care professionals
FLUIDS iQ® is pleased to announce that our laboratory services are now available to health care professionals in the United States.
With the exchange rate presently favoring the U.S. dollar mightily, now is a great time for our friends south of the border to consider using FLUIDS iQ®'s laboratory services at significant cost savings.
Call or email to learn how you can start working with us today for your Zonulin, Food Sensitivity and Saliva Hormone testing needs.